All Outputs (130)

Assessment of a putative oncogene ZNF217 in colorectal cancer by multiplex quantitative real-time PCR. (2002)
Presentation / Conference
ROONEY, P.H., BOONSONG, A., MCFADYEN, M., MCLEOD, H.L., CASSIDY, J. and MURRAY, G.I. 2002. Assessment of a putative oncogene ZNF217 in colorectal cancer by multiplex quantitative real-time PCR. Presented at the 184th Meeting of the Pathological Society of Great Britain and Ireland, 2-5 July 2002, Dublin, Ireland.

Detection of gene amplification is a process that is recognised as a means of identifying oncogenes. This presentation discusses a study in which the gene copy number of a putative oncogene (ZNF217) was assessed in 80 colon carcinomas by multiplex qu... Read More about Assessment of a putative oncogene ZNF217 in colorectal cancer by multiplex quantitative real-time PCR..

Quantitative analysis of the Ah receptor signalling pathway. (2002)
Presentation / Conference
MCFADYEN, M.C.E., ROONEY, P.H. and MURRAY, G.I. 2002. Quantitative analysis of the Ah receptor signalling pathway. Presented at the 2002 British cancer research meeting (BCRM 2002), 30 June - 3 July 2002, Glasgow, UK.

The aryl hydrocarbon receptor (AhR) is a ligand activated receptor. On dimerisation with the aryl hydrocarbon nuclear translocator (ARNT), AhR binds to xenobiotic responsive elements (XREs) that promote the activation of a battery of genes, including... Read More about Quantitative analysis of the Ah receptor signalling pathway..

Assessment of a putative oncogene ZNF217 within amplicon 20q by multiplex quantitative real-time PCR. (2002)
Presentation / Conference
ROONEY, P., BOONSONG, A., MCFADYEN, M., MCLEOD, H.L., CASSIDY, J. and MURRAY, G.I. 2002. Assessment of a putative oncogene ZNF217 within amplicon 20q by multiplex quantitative real-time PCR. Presented at the 2002 British cancer research meeting (BCRM 2002), 30 June - 3 July 2002, Glasgow, UK.

Detection of gene amplification is a recognised process through which oncogenes can be identified. In this study, we have coupled two powerful techniques - laser capture-microdissection and multiplex quantitative real-time PCR - to quickly and accura... Read More about Assessment of a putative oncogene ZNF217 within amplicon 20q by multiplex quantitative real-time PCR..

Metabolically active cytochrome P450 CYP1B1 in solid tumours: a novel target for chemotherapeutic intervention. (2002)
Presentation / Conference
MCFADYEN, M.C.E., MELVIN, W.T. and MURRAY, G.I. 2002. Metabolically active cytochrome P450 CYP1B1 in solid tumours: a novel target for chemotherapeutic intervention. Presented at the 2002 British cancer research meeting (BCRM 2002), 30 June - 3 July 2002, Glasgow, UK.

Cytochrome P450 CYP1B1 is a member of a superfamily of haemoproteins that are central to the oxidative metabolism of a wide variety of endogenous and exogenous compounds. Several of these enzymes have an established role in the metabolic bio-transfor... Read More about Metabolically active cytochrome P450 CYP1B1 in solid tumours: a novel target for chemotherapeutic intervention..

Cytochrome P450 CYP1B1 over-expression in primary and metastatic ovarian cancer. (2001)
Presentation / Conference
MCFADYEN, M.C.E., CRUICKSHANK, M.E., MILLER, I.D., MELVIN, W.T. and MURRAY, G.I. 2001. Cytochrome P450 CYP1B1 over-expression in primary and metastatic ovarian cancer. Presented at the 183rd Meeting of the Pathological Society of Great Britain and Ireland, 3-6 July 2001, Liverpool, UK.

Ovarian cancer is the leading cause of death from gynaecological malignances worldwide. This paper discusses a study in which the presence of CYP1B1 in primary and metastatic ovarian cancer was investigated through immunohistochemistry. The aim of th... Read More about Cytochrome P450 CYP1B1 over-expression in primary and metastatic ovarian cancer..

Cytochrome P450 CYP1B1: a novel mechanism of drug resistance. (2001)
Presentation / Conference
MCFADYEN, M.C.E., MELVIN, W.T. and MURRAY, G.I. 2001. Cytochrome P450 CYP1B1: a novel mechanism of drug resistance. Presented at the 2001 British cancer research meeting (BCRM 2001), 1-4 July 2001, Leeds, UK.

CYP1B1 is a member of the cytochrome P450 enzymes, which are central to the oxidative metabolism of a wide range of substrates, including endogenous compounds involved in cell signaling, environmental carcinogens and anti-cancer drugs. This presentat... Read More about Cytochrome P450 CYP1B1: a novel mechanism of drug resistance..

Cytochrome P450 CYP1B1 in breast cancer. (1998)
Presentation / Conference
MURRAY, G.I., BUCHAN, S., MCFADYEN, M.C.E., MILLER, I.D., PAYNE, S. and MELVIN, W.T. 1998. Cytochrome P450 CYP1B1 in breast cancer. Presented at the 1998 Joint special conference of the British Association for Cancer Research and the Royal Society of Medicine (Oncology Section), 7-8 December 1998, London, UK.

This poster gives an overview of recent research into cytochrome P450 CYP1B1, which has previously been shown to present increased expression in several types of human cancer. This study specifically used immunohistochemistry to investigate the expre... Read More about Cytochrome P450 CYP1B1 in breast cancer..

Cytochrome P450 in human brain tumours. (1997)
Presentation / Conference
MCFADYEN, M.C.E., MELVIN, W.T. and MURRAY, G.I. 1997. Cytochrome P450 in human brain tumours. Presented at the 1997 Joint winter meeting of the British Association for Cancer Research, the Association of Cancer Physicians and the Royal Society of Medicine (Oncology Section), 27-28 November 1997, London, UK.

This presentation reports on a study investigating the presence and cellular localization of individual families of cytochrome P450 enzymes, in both normal brain and primary brain tumours. The immunoreactivity of individual P450s was identified using... Read More about Cytochrome P450 in human brain tumours..

Cytochrome P450 in normal human brain and brain tumours. (1997)
Presentation / Conference
MCFADYEN, M.C.E., MELVIN, W.T. and MURRAY, G.I. 1997. Cytochrome P450 in normal human brain and brain tumours. Presented at the July 1997 Biochemical Society meeting, 29-31 July 1997, Dundee, UK.

Cytochromes P450 are a multi-gene family of constitutive and inducible haem-containing enzymes, with a critical role in the oxidative metabolism of a wide range of environmental chemicals - including carcinogens, toxins and therapeutic drugs. P450s m... Read More about Cytochrome P450 in normal human brain and brain tumours..

Regulation of stomach emptying in pigs. (1987)
Presentation / Conference
GREGORY, P.C., MCFADYEN, M. and RAYNER, D.V. 1987. Regulation of stomach emptying in pigs. Presented at the 1987 Cambridge meeting of the Physiological Society, 18-19 September 1987, Cambridge, UK.

This presentation reports on three experiments into the stomach emptying of pigs during feeding. Each experiment measured the emptying of both solids and liquids from the stomach using a gastric evacuation technique. Two of the experiments also invol... Read More about Regulation of stomach emptying in pigs..