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Professor Giovanna Bermano's Projects (15)

The role of Glutathione Peroxidase 4 (GPX4) and the GPX4 single-nucleotide polymorphism (SNP), rs713041, in metabolic syndrome associated vascular dysfunction Sep 1, 2023 - Apr 30, 2025
High blood sugar, high blood pressure, and obesity are all features of the ‘umbrella term’ metabolic syndrome (MetS) which affects 1 in 3 people over 50 years old in the UK. MetS increases the risk of developing heart disease and in particular the co... Read More about The role of Glutathione Peroxidase 4 (GPX4) and the GPX4 single-nucleotide polymorphism (SNP), rs713041, in metabolic syndrome associated vascular dysfunction.

Investigating the impact of adiposity-redox defence interaction on redox homeostasis and inflammatory and cancer-related pathways in human colonocytes Mar 15, 2021 - Mar 14, 2023
Colorectal cancer is the third most common cancer and the second most common cause of cancer-related death.
Increased body fat have been reported as one of the main factors responsible for the rise in colorectal cancer.
For this reason, a major f... Read More about Investigating the impact of adiposity-redox defence interaction on redox homeostasis and inflammatory and cancer-related pathways in human colonocytes.

Reducing Food Waste Feb 1, 2021 - Jan 31, 2023
The project will analyse fish waste (including heads, frame, tails and trimmings) and process components to extract and refine by-products (oils, nutrients & minerals) creating marketable products to maximise value from the supply chain, reducing the... Read More about Reducing Food Waste.

A human Glutathione Peroxidase 4 3 untranslated region knock-in mouse model to study susceptibility to colon cancer in obesity Apr 1, 2017 - Dec 31, 2021
Colorectal cancer (CRC) incidence is rising steadily and in parallel with increasing prevalence of obesity in Scotland. Recent data indicate that the highest incidence rates are in the North East. The increasing prevalence of obes... Read More about A human Glutathione Peroxidase 4 3 untranslated region knock-in mouse model to study susceptibility to colon cancer in obesity.

The in vitro effect of natural products and anti-cancer agents: targeting the efflux transporter ABCG2 Jul 1, 2017 - Dec 31, 2019
Medicinal use of natural products, such as, extracts from plants have existed for many years particularly in China and are now widely available around the world. Several different types of cancer including breast cancer are becoming insensitive and r... Read More about The in vitro effect of natural products and anti-cancer agents: targeting the efflux transporter ABCG2.

Exploring the relationship between age-related zinc deficiency and obesity and the extent of myocardial damage following acute myocardial infarction Oct 1, 2018 - Jan 1, 2021
Zinc (Zn 2+) is a metal found in trace amounts in the body and plays an essential role in maintaining the healthy functioning of most organs, including the heart. The body does not store zinc in large quantities and so replenishment of Zn 2+ through... Read More about Exploring the relationship between age-related zinc deficiency and obesity and the extent of myocardial damage following acute myocardial infarction.