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Anti-cancer drug interaction with cytochrome P450 CYP1B1. (2003)
Presentation / Conference Contribution
MCFADYEN, M.C.E., MELVIN, W.T. and MURRAY, G.I. 2003. Anti-cancer drug interaction with cytochrome P450 CYP1B1. Presented at the 2003 British cancer research meeting (BCRM 2003), 2-5 July 2003, Bournemouth, UK.

One mechanism potentially amenable to chemotherapeutic intervention involves cytochrome P450 CYP1B1. Our research has established the concept of over-expression of individual forms of cytochrome P450 - in particular CYP1B1 - in a range of solid tumou... Read More about Anti-cancer drug interaction with cytochrome P450 CYP1B1..

Assessment of a putative oncogene ZNF217 in colorectal cancer by multiplex quantitative real-time PCR. (2002)
Presentation / Conference Contribution
ROONEY, P.H., BOONSONG, A., MCFADYEN, M., MCLEOD, H.L., CASSIDY, J. and MURRAY, G.I. 2002. Assessment of a putative oncogene ZNF217 in colorectal cancer by multiplex quantitative real-time PCR. Presented at the 184th Meeting of the Pathological Society of Great Britain and Ireland, 2-5 July 2002, Dublin, Ireland.

Detection of gene amplification is a process that is recognised as a means of identifying oncogenes. This presentation discusses a study in which the gene copy number of a putative oncogene (ZNF217) was assessed in 80 colon carcinomas by multiplex qu... Read More about Assessment of a putative oncogene ZNF217 in colorectal cancer by multiplex quantitative real-time PCR..

Quantitative analysis of the Ah receptor signalling pathway. (2002)
Presentation / Conference Contribution
MCFADYEN, M.C.E., ROONEY, P.H. and MURRAY, G.I. 2002. Quantitative analysis of the Ah receptor signalling pathway. Presented at the 2002 British cancer research meeting (BCRM 2002), 30 June - 3 July 2002, Glasgow, UK.

The aryl hydrocarbon receptor (AhR) is a ligand activated receptor. On dimerisation with the aryl hydrocarbon nuclear translocator (ARNT), AhR binds to xenobiotic responsive elements (XREs) that promote the activation of a battery of genes, including... Read More about Quantitative analysis of the Ah receptor signalling pathway..

Assessment of a putative oncogene ZNF217 within amplicon 20q by multiplex quantitative real-time PCR. (2002)
Presentation / Conference Contribution
ROONEY, P., BOONSONG, A., MCFADYEN, M., MCLEOD, H.L., CASSIDY, J. and MURRAY, G.I. 2002. Assessment of a putative oncogene ZNF217 within amplicon 20q by multiplex quantitative real-time PCR. Presented at the 2002 British cancer research meeting (BCRM 2002), 30 June - 3 July 2002, Glasgow, UK.

Detection of gene amplification is a recognised process through which oncogenes can be identified. In this study, we have coupled two powerful techniques - laser capture-microdissection and multiplex quantitative real-time PCR - to quickly and accura... Read More about Assessment of a putative oncogene ZNF217 within amplicon 20q by multiplex quantitative real-time PCR..

Metabolically active cytochrome P450 CYP1B1 in solid tumours: a novel target for chemotherapeutic intervention. (2002)
Presentation / Conference Contribution
MCFADYEN, M.C.E., MELVIN, W.T. and MURRAY, G.I. 2002. Metabolically active cytochrome P450 CYP1B1 in solid tumours: a novel target for chemotherapeutic intervention. Presented at the 2002 British cancer research meeting (BCRM 2002), 30 June - 3 July 2002, Glasgow, UK.

Cytochrome P450 CYP1B1 is a member of a superfamily of haemoproteins that are central to the oxidative metabolism of a wide variety of endogenous and exogenous compounds. Several of these enzymes have an established role in the metabolic bio-transfor... Read More about Metabolically active cytochrome P450 CYP1B1 in solid tumours: a novel target for chemotherapeutic intervention..

Use of CYP1B1 inhibitors for treating cancer. (2001)
Patent
MURRAY, G.I., MELVIN, W.T. and MCFADYEN, M. 2001. Use of CYP1B1 inhibitors for treating cancer. International patent application PCT/GB2001/000548. International publication number WO/2001/058444 (WO 01/58444 A1), published 16.08.2001. Available from: https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2001058444

CYP1B1 proteins and their role in metabolising or inactivating anti-cancer drugs are disclosed, together with compositions for treating cancer comprising a substance capable of inhibiting CYP1B1 protein and an anti-cancer drug (e.g. docetaxel, paclit... Read More about Use of CYP1B1 inhibitors for treating cancer..

Cytochrome P450 CYP1B1 over-expression in primary and metastatic ovarian cancer. (2001)
Journal Article
MCFADYEN, M.C.E., CRUICKSHANK, M.E., MILLER, I.D., MCLEOD, H.L., MELVIN, W.T., HAITES, N.E., PARKIN, D. and MURRAY, G.I. 2001. Cytochrome P450 CYP1B1 over-expression in primary and metastatic ovarian cancer. British journal of cancer [online], 85(2), pages 242-246. Available from: https://doi.org/10.1054/bjoc.2001.1907

Ovarian cancer is the most frequent cause of death from gynaecological malignancies world wide. Little improvement has been made in the long-term outcome of this disease, with the 5-year survival of patients only 30%. This poor prognosis is due to th... Read More about Cytochrome P450 CYP1B1 over-expression in primary and metastatic ovarian cancer..

Cytochrome P450 CYP1B1 over-expression in primary and metastatic ovarian cancer. (2001)
Presentation / Conference Contribution
MCFADYEN, M.C.E., CRUICKSHANK, M.E., MILLER, I.D., MELVIN, W.T. and MURRAY, G.I. 2001. Cytochrome P450 CYP1B1 over-expression in primary and metastatic ovarian cancer. Presented at the 183rd Meeting of the Pathological Society of Great Britain and Ireland, 3-6 July 2001, Liverpool, UK.

Ovarian cancer is the leading cause of death from gynaecological malignances worldwide. This paper discusses a study in which the presence of CYP1B1 in primary and metastatic ovarian cancer was investigated through immunohistochemistry. The aim of th... Read More about Cytochrome P450 CYP1B1 over-expression in primary and metastatic ovarian cancer..

Cytochrome P450 CYP1B1: a novel mechanism of drug resistance. (2001)
Presentation / Conference Contribution
MCFADYEN, M.C.E., MELVIN, W.T. and MURRAY, G.I. 2001. Cytochrome P450 CYP1B1: a novel mechanism of drug resistance. Presented at the 2001 British cancer research meeting (BCRM 2001), 1-4 July 2001, Leeds, UK.

CYP1B1 is a member of the cytochrome P450 enzymes, which are central to the oxidative metabolism of a wide range of substrates, including endogenous compounds involved in cell signaling, environmental carcinogens and anti-cancer drugs. This presentat... Read More about Cytochrome P450 CYP1B1: a novel mechanism of drug resistance..

Cytochrome P450 CYP3A in human renal cell cancer. (1999)
Journal Article
MURRAY, G.I., MCFADYEN, M.C.E., MITCHELL, R.T., CHEUNG, Y.-L., KERR, A.C. and MELVIN, W.T. 1999. Cytochrome P450 CYP3A in human renal cell cancer. British journal of cancer [online], 79(11-12), pages 1836-1842. Available from: https://doi.org/10.1038/sj.bjc.6690292

Renal cell cancer is the main malignant tumour of the kidney and has an increasing incidence. This type of tumour has a poor prognosis and shows intrinsic resistance to several anti-cancer drugs. The CYP3A P450 family, which consists of three closely... Read More about Cytochrome P450 CYP3A in human renal cell cancer..

Cytochrome P450 CYP1B1 in breast cancer. (1998)
Presentation / Conference Contribution
MURRAY, G.I., BUCHAN, S., MCFADYEN, M.C.E., MILLER, I.D., PAYNE, S. and MELVIN, W.T. 1998. Cytochrome P450 CYP1B1 in breast cancer. Presented at the 1998 Joint special conference of the British Association for Cancer Research and the Royal Society of Medicine (Oncology Section), 7-8 December 1998, London, UK.

This poster gives an overview of recent research into cytochrome P450 CYP1B1, which has previously been shown to present increased expression in several types of human cancer. This study specifically used immunohistochemistry to investigate the expre... Read More about Cytochrome P450 CYP1B1 in breast cancer..

Cytochrome P450 in human brain tumours. (1997)
Presentation / Conference Contribution
MCFADYEN, M.C.E., MELVIN, W.T. and MURRAY, G.I. 1997. Cytochrome P450 in human brain tumours. Presented at the 1997 Joint winter meeting of the British Association for Cancer Research, the Association of Cancer Physicians and the Royal Society of Medicine (Oncology Section), 27-28 November 1997, London, UK.

This presentation reports on a study investigating the presence and cellular localization of individual families of cytochrome P450 enzymes, in both normal brain and primary brain tumours. The immunoreactivity of individual P450s was identified using... Read More about Cytochrome P450 in human brain tumours..

Cytochrome P450 in normal human brain and brain tumours. (1997)
Presentation / Conference Contribution
MCFADYEN, M.C.E., MELVIN, W.T. and MURRAY, G.I. 1997. Cytochrome P450 in normal human brain and brain tumours. Presented at the July 1997 Biochemical Society meeting, 29-31 July 1997, Dundee, UK.

Cytochromes P450 are a multi-gene family of constitutive and inducible haem-containing enzymes, with a critical role in the oxidative metabolism of a wide range of environmental chemicals - including carcinogens, toxins and therapeutic drugs. P450s m... Read More about Cytochrome P450 in normal human brain and brain tumours..

Polyamide profiles of porcine milk and of intestinal tissue of pigs during suckling. (1991)
Journal Article
KELLY, D., KING, T.P., BROWN, D.S. and MCFADYEN, M. 1991. Polyamide profiles of porcine milk and of intestinal tissue of pigs during suckling. Reproduction nutrition development [online], 31(1), pages 73-80. Available from: https://doi.org/10.1051/rnd:19910107

Previous studies have suggested that luminal polyamines can directly influence intestinal differentiation of neonatal rats. The present investigation has demonstrated the presence of high levels of polyamines in porcine milk and in the intestinal tis... Read More about Polyamide profiles of porcine milk and of intestinal tissue of pigs during suckling..

Pattern of gastric emptying in the pig: relation to feeding. (1990)
Journal Article
GREGORY, P.C., MCFADYEN, M. and RAYNER, D.V. 1990. Pattern of gastric emptying in the pig: relation to feeding. British journal of nutrition [online], 64(1), pages 45-58. Available from: https://doi.org/10.1079/bjn19900008

The aims of the present study were to compare the gastric emptying of dry matter (DM) and liquids during the feeding period with that following meal consumption, to clarify the relationship between feeding and gastric emptying, and to investigate how... Read More about Pattern of gastric emptying in the pig: relation to feeding..

Regulation of stomach emptying in pigs. (1987)
Presentation / Conference Contribution
GREGORY, P.C., MCFADYEN, M. and RAYNER, D.V. 1987. Regulation of stomach emptying in pigs. Presented at the 1987 Cambridge meeting of the Physiological Society, 18-19 September 1987, Cambridge, UK.

This presentation reports on three experiments into the stomach emptying of pigs during feeding. Each experiment measured the emptying of both solids and liquids from the stomach using a gastric evacuation technique. Two of the experiments also invol... Read More about Regulation of stomach emptying in pigs..